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Estrogen Study
This study is being done to see whether applying a cream with estradiol (a form of estrogen) to the face can improve overall skin quality and help reduce fine lines and wrinkles in peri- and post-menopausal women, and how this relates to epigenetic changes in the skin. A part of the study will also include applying an extra rapamycin analog cream to the face, which is also believed to improve overall skin quality and help reduce fine lines and wrinkles.
WHY THIS MATTERS
Skin aging in peri- and post-menopausal women is deeply tied to hormonal shifts. This study explores whether topical estradiol can turn back the clock – cellularly.
Eligibility
You MAY qualify if you can answer YES to all:
I am a healthy female (peri or menopausal) between the ages of 40 and 65.
I have not had any cosmetic facial treatments in the last 1-3 months.
I have not had any GLP-1 treatments in the last 6 months.
Study Design and Duration
The study includes daily evening application of study cream for 12 weeks, followed by 4 weeks with no test product use. In total, the study will last 16 weeks or approximately 4 months.
Topical Scalp Serum Containing RLX‑201 in Subjects With Mild‑to‑Moderate Hair Thinning
Purpose of the Study
The purpose of this study is to evaluate the safety, tolerability, and effectiveness of a scalp serum containing RLX‑201 when applied once daily for 20 weeks in men and women with mild‑to‑moderate hair thinning. The study will assess changes in hair density, hair thickness, and overall scalp health using clinical evaluations, imaging tools, and participant self‑assessments.
Eligibility
You MAY qualify if you can answer YES to all:
I am a healthy male or female between the ages of 30 and 50.
Self‑perceived mild‑to‑moderate hair thinning.
I have NOT used minoxidil, light therapy, or other hair growth treatments within 3 months.
I have NOT used medications affecting hair growth (e.g., finasteride, spironolactone, cyproterone acetate, 5‑alpha‑reductase inhibitors) or a GLP-1 within 6 months.
Study Design and Duration
This is a single‑center clinical study lasting approximately 20 weeks. If you agree to participate, you will be asked to attend study visits at the following time points: Baseline, and Weeks 2, 4, 8, 12, 16, and 20.