Menopause Skin: Changes and Treatment Options
Menopause skin changes are real biology, not a failure of willpower or of your skin care routine. So many women tell me their skin changed almost overnight in their late 40s or 50s: drier, thinner, more sensitive, less firm. They are right, and there is a lot we can do about it.
Why skin changes at menopause
Skin is a hormone-responsive organ. As estrogen falls around menopause, the dermis, the deeper supportive layer of skin, gets thinner and collagen production slows [1][2]. Collagen loss is fastest in the first years after menopause, then continues more gradually [3].
Menopause officially begins one year after your last period, but many of these changes start during perimenopause, which can begin 5–10 years before that [3].
What you may notice
- Dryness. Skin holds less water, so it can feel tight and rough, especially in winter [3].
- Thinner skin and easy bruising [3].
- Sagging, jowls and deeper lines as collagen and support decline [3].
- Sensitivity and rashes. Eczema or rosacea may flare [3].
- Adult acne, sometimes for the first time in decades [3].
- More facial hair and thinner scalp hair, often first noticed as a wider part.
- Age spots from years of sun showing up more clearly [3].
- Slower healing [3].
The foundation: what helps at home
Sunscreen every day. A broad-spectrum SPF 30 or higher won't thicken skin, but it helps prevent further thinning and new sun damage [3]. I use my Vitamin E-ssential Sunscreen SPF 44.
A nightly retinoid. Retinoids have the strongest evidence for rebuilding collagen in sun-damaged skin, and a retinoid at night with sunscreen in the morning remains first-line care [4][5]. Menopausal skin can be more sensitive, so start slowly, every second or third night, and build up. My Retinol Level 2 is made for sensitive or out-of-practice skin. For crepey arms, chest and legs, see solutions for crepey skin and my Retinol Body Serum.
Gentle care. Use a mild cleanser instead of soap, a fragrance-free moisturizer with hyaluronic acid or glycerin, and skip harsh scrubs [3].
Hormones and your skin
Many women ask whether hormone therapy will help their skin. In older randomized trials, systemic hormone therapy thickened skin and raised collagen, but trials looking at facial wrinkles have had mixed results [6]. The Menopause Society does not consider skin a reason on its own to start hormone therapy [6]. If you're considering hormones for hot flashes, sleep or bone health, that decision belongs with your gynecologist or primary care doctor, and I'm happy to work with them.
What about estrogen face creams?
The biology is real: estrogen acts on skin cells. But the evidence for estrogen creams on the face is thin. A 2026 systematic review found the studies too varied to combine into one analysis, and few followed women for more than six months [7]. Photodamaged skin seems to respond less than sun-protected skin [8], and some absorption into the body has been reported [9].
Please don't put a vaginal estrogen cream on your face. It is made and labeled for vaginal use. If you are curious about topical estrogen, let's talk about it together.
In-office treatments that can help
Many studies of aesthetic treatments don't report results by menopausal status, so we have less menopause-specific data than we should [10]. With that in mind, here is what I often use:
- Lasers for texture, tone and thinning skin, such as MOXI, Clear + Brilliant and Fotona 4D [3].
- Energy devices for firmness, including Sofwave, Ultherapy and Thermage.
- Injectables when volume and structure have changed: hyaluronic acid fillers and Sculptra.
- Vaginal dryness and comfort. Menopause also affects vaginal tissue. I offer in-office laser treatment for female rejuvenation.
- Hair thinning and unwanted facial hair. See hair loss treatment in NYC. Laser hair removal is an option for facial hair [3].
Taking care of the whole you
Sleep, stress, nutrition and movement show up on your skin. In one study of middle-aged women, both aerobic and resistance training improved skin elasticity, and resistance training also improved dermal thickness [11]. I see menopause as a chance to build habits that help you age beautifully for decades. My longevity dermatology page explains how I think about that, and you can hear more in Hot Flashes and Cool Topics.
Frequently asked questions
Why does my skin get so dry during menopause?
As estrogen falls, skin loses some of its ability to hold water. A mild cleanser and a moisturizer with hyaluronic acid or glycerin can help [3].
Does hormone therapy help menopause skin?
Older trials found systemic hormone therapy can thicken skin and raise collagen, but results for wrinkles are mixed. Skin alone is not a reason to start hormone therapy, so talk with your gynecologist about your overall needs [6].
Should I use estrogen cream on my face?
The evidence for estrogen creams on the face is limited and mixed, and some absorption into the body has been reported [7][9]. Never use vaginal estrogen cream on your face. Talk with your dermatologist first.
What skin care should I use after menopause?
Start with daily broad-spectrum SPF 30 or higher, a gentle cleanser, a fragrance-free moisturizer and a nightly retinoid introduced slowly [3][5].
Why am I breaking out in my 50s?
Hormone shifts before and during menopause can cause adult acne. Teen acne products are often too harsh for thinner, drier skin, so use gentle products and see a dermatologist if it doesn't settle [3].
Can lasers help menopausal skin?
For some women, yes. Lasers and a retinoid can help thinning skin, and other devices can address firmness and texture. Your dermatologist can match the treatment to your skin [3].
About the author
Doris Day, MD, FAAD is a board-certified dermatologist and Clinical Professor of Dermatology at NYU Grossman School of Medicine. Newsweek, with Statista, consistently named her #3 on America's Best Cosmetic Dermatologists. She serves on the American Academy of Dermatology Nominating Committee (2025–present) and she advises major skin care and aesthetic companies on products and devices.
Medically reviewed by Doris Day, MD, FAAD on October 10, 2026. Last updated October 10, 2026.
Day Dermatology & Aesthetics 10 East 70th Street, Suite 1C, New York, NY 10021 (212) 772-0740
Sources
- Thornton MJ. Estrogens and aging skin. Dermatoendocrinol. 2013;5(2):264-270. https://doi.org/10.4161/derm.23872
- Zouboulis CC, et al. Skin, hair and beyond: the impact of menopause. Climacteric. 2022;25(5):434-442. https://doi.org/10.1080/13697137.2022.2050206
- American Academy of Dermatology. Caring for your skin in menopause. https://www.aad.org/public/everyday-care/skin-care-secrets/anti-aging/skin-care-during-menopause
- Griffiths CE, et al. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med. 1993;329(8):530-535. https://doi.org/10.1056/NEJM199308193290803
- Kream E, Fabi S, Boen M. Skinspan. J Cosmet Dermatol. 2025;24:e70432. https://doi.org/10.1111/jocd.70432
- The North American Menopause Society. The 2022 hormone therapy position statement. Menopause. 2022;29(7):767-794. https://doi.org/10.1097/GME.0000000000002028 (with older skin trials: Castelo-Branco 1992, https://doi.org/10.1016/0378-5122(92)90245-y; Maheux 1994, https://doi.org/10.1016/s0002-9378(94)70242-x; Owen 2016, https://doi.org/10.1016/j.fertnstert.2016.06.023)
- Farkas E, et al. Topical estrogen for skin aging: a systematic review of safety and efficacy. J Am Acad Dermatol. 2026;94(1):212-215. https://doi.org/10.1016/j.jaad.2025.08.050
- Rittié L, et al. Induction of collagen by estradiol. Arch Dermatol. 2008;144(9):1129-1140. https://doi.org/10.1001/archderm.144.9.1129
- Troxel J, et al. Topical estrogen therapy for aging skin: current evidence and clinical considerations. JAAD Reviews. 2026;7:73-80. https://doi.org/10.1016/j.jdrv.2025.12.003
- Viscomi B, Muniz M, Sattler S. J Cosmet Dermatol. 2025;24(Suppl 4):e70393. https://doi.org/10.1111/jocd.70393
- Nishikori S, et al. Sci Rep. 2023;13:10214. https://doi.org/10.1038/s41598-023-37207-9
Estrogen Study
This study is being done to see whether applying a cream with estradiol (a form of estrogen) to the face can improve overall skin quality and help reduce fine lines and wrinkles in peri- and post-menopausal women, and how this relates to epigenetic changes in the skin. A part of the study will also include applying an extra rapamycin analog cream to the face, which is also believed to improve overall skin quality and help reduce fine lines and wrinkles.
WHY THIS MATTERS
Skin aging in peri- and post-menopausal women is deeply tied to hormonal shifts. This study explores whether topical estradiol can turn back the clock – cellularly.
Eligibility
You MAY qualify if you can answer YES to all:
I am a healthy female (peri or menopausal) between the ages of 40 and 65.
I have not had any cosmetic facial treatments in the last 1-3 months.
I have not had any GLP-1 treatments in the last 6 months.
Study Design and Duration
The study includes daily evening application of study cream for 12 weeks, followed by 4 weeks with no test product use. In total, the study will last 16 weeks or approximately 4 months.
Topical Scalp Serum Containing RLX‑201 in Subjects With Mild‑to‑Moderate Hair Thinning
Purpose of the Study
The purpose of this study is to evaluate the safety, tolerability, and effectiveness of a scalp serum containing RLX‑201 when applied once daily for 20 weeks in men and women with mild‑to‑moderate hair thinning. The study will assess changes in hair density, hair thickness, and overall scalp health using clinical evaluations, imaging tools, and participant self‑assessments.
Eligibility
You MAY qualify if you can answer YES to all:
I am a healthy male or female between the ages of 30 and 60.
Self‑perceived mild‑to‑moderate hair thinning.
I have NOT used minoxidil, light therapy, or other hair growth treatments within 3 months.
I have NOT used medications affecting hair growth (e.g., finasteride, spironolactone, cyproterone acetate, 5‑alpha‑reductase inhibitors) or a GLP-1 within 6 months.
Study Design and Duration
This is a single‑center clinical study lasting approximately 20 weeks. If you agree to participate, you will be asked to attend study visits at the following time points: Baseline, and Weeks 2, 4, 8, 12, 16, and 20.
